16 February 2005 Polymer microstructures for cellular growth studies
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Abstract
The understanding and control of cell growth in confined microenvironments has application to a variety of fields including cell biosensor development, medical device fabrication, and pathogen control. While the majority of work in these areas has focused on mammalian and bacterial cell growth, this study reports on the growth behavior of fungal cells in three-dimensionally PDMS microenvironments of a scale similar to that of individual hyphae. Confinement was found to affect filament branching rate and angle. Overall, fungal hyphae demonstrate much more coordinated behavior during confinement than observed during growth on simple planar unconfined substrates. The remarkable difference of fungal growth behaviour observed in the PDMS microenvironments compared to open, unrestricted environments suggests that three-dimensional microstructures could be used to control and alter fungal motility.
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Luisa Filipponi, Luisa Filipponi, Kristi L. Hanson, Kristi L. Hanson, Abraham Phillip Lee, Abraham Phillip Lee, Dan V. Nicolau, Dan V. Nicolau, } "Polymer microstructures for cellular growth studies", Proc. SPIE 5651, Biomedical Applications of Micro- and Nanoengineering II, (16 February 2005); doi: 10.1117/12.584143; https://doi.org/10.1117/12.584143
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