7 March 2005 Pulse modulation image sensors for on-chip bioimaging and biosensing applications
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Abstract
Image sensors with pulse modulation measurement scheme are fabricated for bioimaging and biosensing ap-plications. We designed pulse modulation photosensors, a 64×64-pixels image sensor for in vitro bioimaging, and a 176×144-pixels (QCIF) image sensor for in vivo bioimaging. We demonstrated the feasibility of the pulse modulation measurement scheme for biosensing applications. We obtained a dynamic range of 120dB and minimum sensing intensity level of 2nW/cm2. We also confirmed that 0.2% of intensity change is detectable at the minimum intensity region. An in vitro, on-chip imaging of a mouse hippocampus was successfully demonstrated. A sensor module for in vivo imaging is also developed.
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Takashi Tokuda, Takashi Tokuda, David C. Ng, David C. Ng, Hideki Okamoto, Hideki Okamoto, Keiichiro Kagawa, Keiichiro Kagawa, Jun Ohta, Jun Ohta, Masahiro Nunoshita, Masahiro Nunoshita, } "Pulse modulation image sensors for on-chip bioimaging and biosensing applications", Proc. SPIE 5677, Sensors and Camera Systems for Scientific and Industrial Applications VI, (7 March 2005); doi: 10.1117/12.588168; https://doi.org/10.1117/12.588168
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