Applications of multiphoton polarization and generalized polarization microscopy in elucidating transdermal delivery pathways

Yen Sun; Jiunn-Wen Su; Wen Lo; Sung-Jan Lin; Shiou-Hwa Jee; Chen-Yuan Dong

doi:10.1117/12.587426

25 April 2005 Applications of multiphoton polarization and generalized polarization microscopy in elucidating transdermal delivery pathways

Yen Sun, Jiunn-Wen Su, Wen Lo, Sung-Jan Lin, Shiou-Hwa Jee, Chen-Yuan Dong

Author Affiliations +

Proceedings Volume 5686, Photonic Therapeutics and Diagnostics; (2005) https://doi.org/10.1117/12.587426
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Physical and chemical enhancement techniques have proven to be useful in promoting transdermal delivery of therapeutic agents. However, it has been difficult to follow the changes to the skin during these processes microscopically. In this work, we use multiphoton polarization (P) and generalized polarization (GP) imaging of the membrane probe Laurdan to monitor changes to the stratum corneum under conditions of chemically enhanced delivery by oleic acid. We show that the combination of P and GP Laurdan imaging helps to reveal both the physical and chemical changes to the stratum corneum under enhanced delivery. Our work can help to develop more efficient transdermal delivery strategies.

Citation Download Citation

Yen Sun, Jiunn-Wen Su, Wen Lo, Sung-Jan Lin, Shiou-Hwa Jee, and Chen-Yuan Dong "Applications of multiphoton polarization and generalized polarization microscopy in elucidating transdermal delivery pathways", Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); https://doi.org/10.1117/12.587426

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