25 April 2005 Development of a brain tumor model for investigating the effects of photodynamic and anti-angiogenic therapies
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Abstract
An in vivo shell-less chick chorioallantoic membrane (CAM) brain tumor model has been developed to investigate the effects of photodynamic therapy (PDT) and anti-antiogenic treatments. Multicellular human glioma spheroids were placed on the CAM at day 7 of embryonic development. Angiogenesis was observed four days post implantation. Significant damage to the CAM vasculature was observed immediately following 5-aminolevulinic acid (ALA) mediated PDT.
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Nzola De Magalhaes, Nzola De Magalhaes, Chung-Ho Sun, Chung-Ho Sun, Steen J. Madsen, Steen J. Madsen, Henry Hirschberg, Henry Hirschberg, Bruce J. Tromberg, Bruce J. Tromberg, } "Development of a brain tumor model for investigating the effects of photodynamic and anti-angiogenic therapies", Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); doi: 10.1117/12.596910; https://doi.org/10.1117/12.596910
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