25 April 2005 Laser skin welding using water absorption and heat management
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Laser skin welding (LSW) is being pursued for scarless wound healing. We present a new LSW approach using a contact glass slide over the sample and rapid scanning of the laser beam around the area to be welded. This led to dramatic improvement in welding efficacy. A 400 mW beam at 1455 nm with a focused spot diameter of 80 μm in air was scanned at a rate of 5mm/second over a 5mm line of incision in 5 mm x 20 mm human skin samples. Histological analysis of the welded samples using hematoxyline and eosin under unpolarized light showed full-thickness full-length weld, and that with picrosirius red F3BA stain under polarized light revealed that there was no appreciable damage. Measured tensile strength of 2.1 kg/cm2 is markedly greater than our previous LSW results of 1.05 ± 0.19 kg/cm2, which is greater than the typical values of 0.4 kg/cm2 obtained using sutures.
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Rabindra K. Halder, Alvin Katz, Howard E. Savage, Vladimir Kartazayev, Steven A. McCormick, Yury Budansky, Misu Paul, Richard B. Rosen, Robert R. Alfano, "Laser skin welding using water absorption and heat management", Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); doi: 10.1117/12.592795; https://doi.org/10.1117/12.592795

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