25 April 2005 Nd:YAG laser irradiation in combination with contact tissue cooling for creation of subsurface thermal lesions
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Abstract
This study investigates deep laser coagulation of tissue in combination with contact cooling of the tissue surface for potential use in noninvasive urology procedures. A laser probe was designed, built, and tested for combination Nd:YAG laser irradiation and sapphire contact cooling of liver and skin tissue samples, ex vivo. Gross and histologic examination was used to quantify thermal lesion dimensions. Liver lesions measured 5.5 ± 0.3 mm in diameter, while preserving the tissue surface to a depth of 2.1 ± 0.2 mm (n = 5). Skin lesions measured 4.3 ± 0.9 mm in diameter, while preserving the skin surface to a depth of 1.1 ± 0.2 mm (n = 6). There were no statistical differences in lesion diameter and layer of preserved tissue between contact (sapphire) cooling and prior non-contact (cryogen spray) cooling results for a given tissue type (p > 0.05). Noninvasive laser procedures targeting tissue structures for thermal coagulation within a few millimeters of the tissue surface are feasible and may expand the use of combined laser/cooling techniques for applications in urology. In vivo animal studies are currently in development to optimize the laser and cooling parameters for potential clinical applications.
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Rahayu Ramli, Rahayu Ramli, Chia-Chun Chung, Chia-Chun Chung, Nathaniel M. Fried, Nathaniel M. Fried, Nicholas Franco, Nicholas Franco, Michael H. Hayman, Michael H. Hayman, } "Nd:YAG laser irradiation in combination with contact tissue cooling for creation of subsurface thermal lesions", Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); doi: 10.1117/12.586361; https://doi.org/10.1117/12.586361
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