25 April 2005 Transcranial measurement of diffuse light reflectance from brain edema in rats: effect of change in the blood flow
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Abstract
We assumed that edema causes a decrease in the scattering coefficient of brain tissue and hence a decrease in the intensity of diffuse reflectance from the brain. On the basis of this assumption, we attempted to transcranially detect a formation of brain edema by measuring diffuse light reflectance. In rats, edema was induced by making a cold injury in the brain. The skull was irradiated with 633-nm and 532-nm laser light delivered through an optical fiber, and the diffuse light reflectance from the brain was collected with another optical fiber. We observed that reflectance intensities were significantly decreased around the cold injury both at 633 nm and 532 nm, suggesting that scattering coefficient of brain tissue was reduced due to a formation of edema in this area. In the injury, reflectance intensity was increased at 532 nm, indicating that cerebral blood volume was decreased in this region.
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Yoshinori Ueda, Shunichi Sato, Hidetoshi Ooigawa, Hiroshi Nawashiro, Daizoh Saitoh, Katsuji Shima, Yoshiaki Okada, Hiroshi Ashida, Minoru Obara, "Transcranial measurement of diffuse light reflectance from brain edema in rats: effect of change in the blood flow", Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); doi: 10.1117/12.590008; https://doi.org/10.1117/12.590008
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