Transendoscopic laser surgery has been performed in large animals since 1984. It is used to treat many upper respiratory disorders, as well as urogenital diseases. Initially, the Nd:YAG laser was the laser of choice until the early 1990's, when smaller, more compact diode lasers entered the veterinary field. In the mid 1980's, several attempts were made to transmit CO2 laser energy transendoscopically. True success was not obtained until 2004 when the OmniGuide CO2 Laser Hollow Light Guide (fiber) was fabricated. Although there is attenuation of energy, this very flexible fiber allows the CO2 laser to be used transendoscopically for incision and ablation of tissue. Both healing and recuperation time are reduced, compared to other wavelengths transmitted through solid quartz fiber. The OmniGuide fiber can be coupled to the output ports of CO2 lasers commonly used in veterinary medicine. Transendoscopic application of the CO2 laser is advantageous in that there is no endoscopic white-out, no volume heating of tissue, and it provides accurate means of performing upper respiratory surgery in the standing large animal.