Modulation of photodynamic activity with Photofrin: effect of dose, time interval, fluence, and delivery system

Greta M. Garbo; Jonathan R. Ballard; Linda T. Harrison; Peter K. Kik; T. J. Wieman; Victor H. Fingar

doi:10.1117/12.589304

8 April 2005 Modulation of photodynamic activity with Photofrin: effect of dose, time interval, fluence, and delivery system

Greta M. Garbo, Jonathan R. Ballard, Linda T. Harrison, Peter K. Kik, T. J. Wieman, Victor H. Fingar

Author Affiliations +

Proceedings Volume 5689, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIV; (2005) https://doi.org/10.1117/12.589304
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

A goal of our laboratory is to accurately define the parameters of light dose and drug dose that contribute to tissue destruction after Photodynamic therapy (PDT). Using Photofrin as sensitizer, we examined a range of drug doses, various intervals between injection and light treatment, and various fluence rates. The effect of Photofrin photosensitizer encapsulated in liposomal delivery vehicle was also studied. Three liposome delivery vehicles were chosen to deliver the photosensitizer in vivo: DPPC/cholesterol, DMPC/HPC and stealth liposomes. Tumor response and microvessel behaviour were examined in tumor and surrounding skin in a mouse model. Under these conditions, better selectivity of tissue damage was seen using some of the treatment. These data might be used to design better clinical protocols for patient care. In memory of Dr. Victor Fingar (Supported by R01 CA51771).

Citation Download Citation

Greta M. Garbo, Jonathan R. Ballard, Linda T. Harrison, Peter K. Kik, T. J. Wieman, and Victor H. Fingar "Modulation of photodynamic activity with Photofrin: effect of dose, time interval, fluence, and delivery system", Proc. SPIE 5689, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIV, (8 April 2005); https://doi.org/10.1117/12.589304

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