13 April 2005 Depth-resolved low-coherence backscattering spectroscopy
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Although the phenomenon of coherent backscattering (CBS) in non-biological media has generated substantial research interest, observing CBS in biological tissue has been extremely difficult. Thus, this phenomenon has awaited its applications in tissue optics over the last two decades. Here we demonstrate depth-resolved spectroscopic elastic-light scattering measurements in tissue by use of low-coherent backscattering (LCBS) spectroscopy. The depth resolution is achieved by exploiting the nature of the LCBS peak that contains information about a wide range of tissue depths. We further demonstrate that the depth-resolved LCBS spectroscopy has the potential for identifying the location of the origin of precancerous transformations in the colon at an early, previously undetectable stage.
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Young L. Kim, Young L. Kim, Yang Liu, Yang Liu, Vladimir Turzhitsky, Vladimir Turzhitsky, Ramesh K. Wali, Ramesh K. Wali, Hemant K. Roy, Hemant K. Roy, Vadim Backman, Vadim Backman, } "Depth-resolved low-coherence backscattering spectroscopy", Proc. SPIE 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, (13 April 2005); doi: 10.1117/12.591314; https://doi.org/10.1117/12.591314

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