13 April 2005 Monitoring refractive index variations in turbid media using phase-sensitive frequency-domain OCT
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Abstract
Functional imaging of clear and tissue-simulating phantoms using phase-resolved swept-source spectroscopic OCT (PhS-SSOCT) is described. Superior sensitivity of PhS-SSOCT technique to monitor ultra-small changes in sample refractive index is demonstrated using aqueous solutions of glucose and aqueous suspensions of polystyrene microspheres and glucose. Glucose-induced changes in the phase are found to be 0.039 rad/mM and 0.037 rad/mM in the 200 μm-thick cell for clear and turbid media, respectively, that is in good agreement with our previous data obtained using differential-phase time-domain OCT. Obtained results suggest that PhS-SSOCT has a potential for noninvasive, depth-resolved, real-time quantitative monitoring of concentrations of glucose and other analytes with high accuracy.
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Kirill V. Larin, Rinat O. Esenaliev, Eunha Kim, Sanghoon Oh, Massoud Motamedi, Thomas E. Milner, "Monitoring refractive index variations in turbid media using phase-sensitive frequency-domain OCT", Proc. SPIE 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, (13 April 2005); doi: 10.1117/12.590534; https://doi.org/10.1117/12.590534
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