13 April 2005 Ultrahigh-resolution polarization-sensitive optical coherence tomography
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We present, to the best of our knowledge, the first ultrahigh resolution, polarization sensitive OCT images of human tissue in vivo. The system is based on a Mach Zehnder interferometer and a transversal scanning of the sample. A broadband superluminescent diode with a center wavelength of 897nm and a bandwidth (FWHM) of 155nm was used. The depth resolution of the system was measured with ~ 4 micrometer in air. The actual scanning speed of 1000 transversal lines per second enables the acquisition of an image (B-scan) consisting of 1600(x) x 1000(z) pixels in 1 second. The whole signal is recorded by a polarization sensitive detection unit at the interferometer exit which enables a phase resolved measurement. From the recorded data we were able to obtain backscattered intensity, retardation and cumulative fast axis orientation of the sample. Images of these parameters obtained from a technical sample and from a human cornea in vivo are presented.
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Michael Pircher, Erich Goetzinger, Rainer Andreas Leitgeb, Harald Sattmann, Christoph K. Hitzenberger, "Ultrahigh-resolution polarization-sensitive optical coherence tomography", Proc. SPIE 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, (13 April 2005); doi: 10.1117/12.592700; https://doi.org/10.1117/12.592700

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