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23 March 2005 High-accuracy noncontact optical flow sensor for monitoring drug delivery
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External and implantable infusion pumps are deployed in an ever widening variety of therapies. These devices are continually driven to increasing accuracy, smaller size, and lower cost. One opportunity for advancement in infusion pump technology is the improvement of closed loop monitoring of the delivery dosage of pharmaceuticals. An optical flow sensor has been designed, developed, and demonstrated based on a non-contact thermal time of flight architecture. The device is a diffraction based sensor. An analytical theory of operation will be presented. Simulations were conducted using a computational model based on heat transfer and computational fluid dymanics combined with diffraction optics calculations. These simulations were corroborated by experimental observations. The sensor has been demonstrated on several prototype platforms, including a prototype using telecommunications devices and packaging technology at a size of 20 mm x 20 mm x 5 mm. Experimental results will be presented demonstrating monitoring of flow rates between 240 nl/sec to 800 nL/sec with accuracies of better than 1% CV.
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Brian Catanzaro, David Gillett, Meghan Simmons, Jeremy Fennelly, and Burton Sage Jr. "High-accuracy noncontact optical flow sensor for monitoring drug delivery", Proc. SPIE 5691, Optical Fibers and Sensors for Medical Applications V, (23 March 2005);

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