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23 March 2005 Hydrophobic chalcogenide fibers for cell-based bio-optical sensors
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Abstract
Chalcogenide fibers are shown to exhibit a hydrophobic surface behavior which results in detection enhancement for organic species in aqueous solutions. We use these fibers to monitor the infrared signature of human lung cells and detect the presence of toxic agents in the cell surrounding media. The signal is collected using a fiber evanescent wave spectroscopy set up with live human cells acting as a sensitizer for detection of minute quantities of toxicant. A monolayer of human alveolar epithelial cells form strong attachment at the surface of the fiber sensing zone and live in contact with the fiber while their IR spectra is collected remotely. Biochemical change in the living cells are detected during exposure to toxic agents. Variations in the spectroscopic features of the cells are observed in different spectral regions. Finally, the toxicity of Te2As3Se5 fibers is investigated.
© (2005) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Pierre Lucas, Mark R. Riley, Michelle A. Solis, Christophe Juncker, Jayne Collier, and Dianne E. Boesewetter "Hydrophobic chalcogenide fibers for cell-based bio-optical sensors", Proc. SPIE 5691, Optical Fibers and Sensors for Medical Applications V, (23 March 2005); https://doi.org/10.1117/12.610828
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