1 April 2005 Drying drops of biological liquids: dynamics of the optical and mechanical properties. Application in rapid medical diagnostics
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Abstract
The dynamical characteristics of integral mechanical properties of drying droplets of blood serum, urine and saliva were studied by measuring the acoustic-mechanical impedance (AMI) using a computer-controlled setup described earlier. The method is based on the following idea. When a 5μl liquid drop is drying on the surface of a quartz resonator plate oscillating at a constant frequency (equal to the resonance frequency of an unloaded resonator, 60 kHz), there arises a shear wave highly sensitive to the formation and growth of a new phase at the liquid-quartz interface. The experimental setup measures a change in the complex electric conductivity of the liquid-quartz system, calculates the parameters of the AMI dynamics in the drying drop, and displays their variation on the monitor at the real time scale in the form of a curve. At a time the optical The properties of drying drops were observed. For each disease or a physiological state the geometrical features of the curves were extracted and then the shape indices were calculated. In the cases under study each "pathology" group differed from the "norm" by its specific shape index, by which diseases of other nature did not differ. Possible mechanisms behind formation of the morphological and dynamical differences in drying drops of biological liquids of healthy and sick people are discussed.
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Tatiana A. Yakhno, Anatoly G. Sanin, Vladimir G. Yakhno, Artem S. Pelyushenko, Michael B. Dowell, Christina Vacca, Valentina A. Goutorova, "Drying drops of biological liquids: dynamics of the optical and mechanical properties. Application in rapid medical diagnostics", Proc. SPIE 5692, Advanced Biomedical and Clinical Diagnostic Systems III, (1 April 2005); doi: 10.1117/12.591556; https://doi.org/10.1117/12.591556
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