1 April 2005 Multivariate analysis of Monte Carlo generated images for diagnosis of dysplastic lesions
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Abstract
Early detection of malignant melanoma is critical to improve the survival rates of patients with this aggressive malignancy. We constructed an imaging system employing two liquid-crystal tunable filters to acquire in vivo spectral images of dysplastic lesions from patients at 31 wavelengths from 500 to 950nm. These reflectance images were analyzed in search of optical signatures for quantitative characterization of dysplastic nevi and malignant melanoma. A principal component analysis (PCA) algorithm was developed to examine the spectral imaging data in the component space and an index of spreading of clustering pixels (SCP) was defined to measure the degree of clustering in the distribution of image pixel scores in a component space. We found that SCP of differential polarimetric images correlate strongly with the degree of dysplasia for 4 lesions. However, many questions remain unanswered on the relations between PCA results and the spatial and spectral characteristics of the image data because of limited spectral image data from the patients. To fully improve our understanding on the multivariate analysis of spectral imaging data, we have developed a parallel Monte Carlo code to efficiently generate reflectance images from given distribution of optical parameters in a skin lesion phantom. With this tool, we have investigated numerically the dependence of score distribution and SCP in the component sub-spaces on lesion size and position. These numerical results provide a foundation for our future study to identify optical signature of dysplastic lesion and melanoma in the skin.
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Jun Q. Lu, Jun Q. Lu, Yuanming Feng, Yuanming Feng, Rosa E. Cuenca, Rosa E. Cuenca, Kai Li, Kai Li, Yalin Ti, Yalin Ti, Kenneth M. Jacobs, Kenneth M. Jacobs, Shawn B. Jackson, Shawn B. Jackson, Ron R. Allison, Ron R. Allison, Claudio H. Sibata, Claudio H. Sibata, Gordon H. Downie, Gordon H. Downie, Xin-Hua Hu, Xin-Hua Hu, } "Multivariate analysis of Monte Carlo generated images for diagnosis of dysplastic lesions", Proc. SPIE 5692, Advanced Biomedical and Clinical Diagnostic Systems III, (1 April 2005); doi: 10.1117/12.589649; https://doi.org/10.1117/12.589649
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