1 April 2005 Ultrasound-tagged light assessment of osteoporosis
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There have been several attempts to detect bone structural changes using optical techniques. H.G. Eberle et al. have used ultrafast optical techniques on the finger in trans-illumination and have shown an excellent correlation between their measurements of the scattering coefficient and bone mineral density obtained using dual X-ray absorption (DXA) imaging. Encouraged by these results, we have developed a system based on the combination of cw laser light and low-frequency ultrasound to probe the bone structure. The physical principle of this system is the detection of laser light diffusing in the bone tissue modulated ("tagged") by a low-frequency ultrasound pulse, which allows a local measurement of the attenuation coefficient. The basic assumption of the technique is that the main factor of attenuation changes in the bone of elderly patients is a scattering change due to osteoporosis, and therefore attenuation measurements directly reflect the scattering properties of the bone. We present a preliminary series of clinical experiments showing that this technique allows determining the bone scattering modification inside the trabecular bone. In this series of clinical experiments, the scattering coefficient determined using the optical technique is compared with the bone mineral density obtained using dual X-ray absorption in a group of 9 patients. A correlation of 0.84 (p=0.05) was found, showing the potential of this technique for the assessment of osteoporosis.
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Aner Lev, Aner Lev, Evgeni Rubanov, Evgeni Rubanov, Bruno Sfez, Bruno Sfez, Shraga Shany, Shraga Shany, Joseph Foldes, Joseph Foldes, } "Ultrasound-tagged light assessment of osteoporosis", Proc. SPIE 5692, Advanced Biomedical and Clinical Diagnostic Systems III, (1 April 2005); doi: 10.1117/12.588553; https://doi.org/10.1117/12.588553

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