In vivo imaging polarimeter for oral precancer detection

Jungrae Chung; Woonggyu Jung; Petra Wilder-Smith; Zhongping Chen

doi:10.1117/12.589401

28 April 2005 In vivo imaging polarimeter for oral precancer detection

Jungrae Chung, Woonggyu Jung, Petra Wilder-Smith, Zhongping Chen

Author Affiliations +

Proceedings Volume 5693, Optical Tomography and Spectroscopy of Tissue VI; (2005) https://doi.org/10.1117/12.589401
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

The Mueller matrix describes all the polarizing properties of a sample, and therefore the optical differences between non-cancerous and pre-cancerous tissue should be present within the matrix elements. We present in this paper that a high speedpolarimetry system generates 16 full Mueller matrices to characterize tissues. Feature extraction is done on the Mueller matrix elements resulting in the depolarizance and retardance images by polar decomposition to detect and classify of early oral cancers and pre-cancerous changes in epithelium, such as dysplasia. These images are compared with orthogonal polarization image and analyzed in an attempt to determine the important factors for the identification of cancerous lesions from their benign counterparts. Our results indicate that polarimetry has potential as a method for the in vivo early detection and diagnosis of oral premalignancy and malignancy.

Citation Download Citation

Jungrae Chung, Woonggyu Jung, Petra Wilder-Smith, and Zhongping Chen "In vivo imaging polarimeter for oral precancer detection", Proc. SPIE 5693, Optical Tomography and Spectroscopy of Tissue VI, (28 April 2005); https://doi.org/10.1117/12.589401

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