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28 April 2005 Integrated photonic system for optical imaging and spectroscopy: non-invasive monitoring of brain tumor (glioblastoma) angiogenesis
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Abstract
In this paper we describe a novel integrated photonic system that can be applied for optical imaging of intracranial brain tumor (Glioblastoma) angiogenesis in small animal model. A non-invasive multi-modality approach based on near infrared spectroscopy (NIRS) technique namely: Steady State Diffuse Optical Spectroscopy (DOS) along with Magnetic Resonance Imaging (MRI) technique is applied for monitoring the concentration of oxyhemoglobin, deoxyhemoglobin and water within tumor region and for studying the vascular status of tumor and the physiological changes that occur during brain tumor angiogenesis.
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Vishal Saxena, Jon F. Nielsen, Walter Laug, and Marvin Nelson "Integrated photonic system for optical imaging and spectroscopy: non-invasive monitoring of brain tumor (glioblastoma) angiogenesis", Proc. SPIE 5693, Optical Tomography and Spectroscopy of Tissue VI, (28 April 2005); https://doi.org/10.1117/12.588720
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