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28 April 2005 Spectrally constrained NIR tomography for breast imaging: simulations and clinical results
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Abstract
A multi-spectral direct chromophore and scattering reconstruction for frequency domain NIR tomography has been implemented using constraints of the known molar spectra of the chromophores and a Mie theory approximation for scattering. This was tested in a tumor-simulating phantom containing an inclusion with higher hemoglobin, lower oxygenation and contrast in scatter. The recovered images were quantitatively accurate and showed substantial improvement over existing methods; and in addition, showed robust results tested for up to 5% noise in amplitude and phase measurements. When applied to a clinical subject with fibrocystic disease, the tumor was visible in hemoglobin and water, but no decrease in oxygenation was observed, making oxygen saturation, a potential diagnostic indicator.
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Subhadra Srinivasan, Brian W. Pogue, Shudong Jiang, Hamid Dehghani, and Keith D. Paulsen "Spectrally constrained NIR tomography for breast imaging: simulations and clinical results", Proc. SPIE 5693, Optical Tomography and Spectroscopy of Tissue VI, (28 April 2005); doi: 10.1117/12.590576; https://doi.org/10.1117/12.590576
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