Complement activation approaches for use in conjunction with PDT for cancer treatment

Mladen Korbelik; Graeme J. Dougherty

doi:10.1117/12.589548

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15 April 2005 Complement activation approaches for use in conjunction with PDT for cancer treatment

Mladen Korbelik; Graeme J. Dougherty

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Proceedings Volume 5695, Optical Interactions with Tissue and Cells XVI; (2005) https://doi.org/10.1117/12.589548
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Photodynamic therapy (PDT) has become an established clinical modality for the treatment of a variety of cancers and other lesions. Rapid induction of a massive damage in targeted cancerous tissue by PDT triggers a strong host response whose primary purpose is to contain the perturbed local homeostasis, remove the dead tissue and promote tissue healing at the affected site. Recent characterization of the participation of the complement system in the PDT-induced host response has prompted the hypothesis that further amplification of PDT-elicited complement activation can potentiate the antitumor effect of PDT yielding superior therapeutic gains. After discussing the nature of complement activity directed against autologous tissue and the evidence of complement system engagement following PDT treatment, this report describes various approaches for successfully potentiating the PDT-induced complement activation illustrating the perspectives of this strategy for the clinical management of cancer.

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Mladen Korbelik and Graeme J. Dougherty "Complement activation approaches for use in conjunction with PDT for cancer treatment", Proc. SPIE 5695, Optical Interactions with Tissue and Cells XVI, (15 April 2005); https://doi.org/10.1117/12.589548

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