15 April 2005 Determination of the threshold dose using depth of necrosis measurement
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Abstract
The use of simple models to understand basic features of the Photodynamic Therapy may contribute to the solid establishment of its dosimetry enhancing its degree of clinical susccess . In this work we have used normal rat liver as a prototype for the determination of threshold dose as a function of photosensitize concentration in the tissue. For this purpose we have investigated the depth of necrosis induced by photodynamic therapy when varying doses of light and photosensitizer (Photogema) concentrations are employed. All experiments were done with a light intensity of 250 mW/cm2. We have determined that the depth of necrosis depends on the photosensitizer concentration injected in the animal. Stablishing the correlation of the light intensity at the point where lies the separation line between necrosed and health tissue, we measure the threshold dose.
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Juliana Ferreira, Cristina Kurachi, Lilian Tan Moriyama, Luis Gustavo Marcassa, Orlando de Castro e Silva, Sergio Zucoloto, Vanderlei Salvador Bagnato, "Determination of the threshold dose using depth of necrosis measurement", Proc. SPIE 5695, Optical Interactions with Tissue and Cells XVI, (15 April 2005); doi: 10.1117/12.588245; https://doi.org/10.1117/12.588245
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