15 April 2005 Development of an intravascular laser treatment with an infrared free electron laser
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Abstract
A cholesterol ester is selective dissociated by MIR-FEL irradiation with wavelength of 5.75 μm correspond to C=O stretching vibration of ester bond. To evaluate the optimum irradiation condition for cholesterol ester decomposition without normal endothelium cell damage, we perform a 5.75 μm-FEL irradiation to a two-layer vessel model which is cholesterol oleate as a model of atherosclerotic lesions and gelatin as a model of endothelial cells. The ester decomposition and gelatin damege depends on total power density of 5.75 μm-FEL provided the two-layer model. Exposure of the FEL with power density exceed 17.8 W/cm2 decomposed cholesterol ester thorough gelain layer of 15 μm thickness. If FEL with power density of 25.0 W/cm2 is exposed during 10 seconds, the gelatin is evaporized. Therefore, the optimum condition for ester decomposition without gelatin evaporation is between 75 J/cm2 from 20 J/cm2 in the case of 15 μm gelatin layer thickness. The maximum ester decomposition rate without gelatin vaporization is 71% on FEL of power density of 17.8 W/cm2 for 10 seconds.
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Sachiko Suzuki-Yoshihashi, Sachiko Suzuki-Yoshihashi, Katsunori Ishii, Katsunori Ishii, Tomoko Sano, Tomoko Sano, Kunio Awazu, Kunio Awazu, } "Development of an intravascular laser treatment with an infrared free electron laser", Proc. SPIE 5695, Optical Interactions with Tissue and Cells XVI, (15 April 2005); doi: 10.1117/12.591912; https://doi.org/10.1117/12.591912
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