25 April 2005 Quantitative ultrasound modulated light tomography
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Abstract
Ultrasound modulated light tomography (UMLiT) is a very attractive method for optical imaging of turbid media. Different schemes have been developed for effectively discriminating between the non-modulated and modulated photons and locate absorbing inhomogeneities. L. Wang has shown the possibility of using chirped ultrasound as well as Radon transformed-based tomography for three-dimensional imaging, C. Boccara has demonstrated the use of ultrafast cameras in order to increase the signal to noise ratio. Our group has shown the use of pulsed ultrasound for three-dimensional localization. However, although there have been a strong effort towards imaging objects in phantoms, very few experiments have shown quantitative results probing the limits of the technique in terms of resolution and sensitivity. We will present experimental results obtained in a reflection configuration. In a first series of experiments we present results obtained on living mice and rabbits, showing two and three-dimensional representations. In a second series of experiments, we have prepared different Agar-based phantoms in which small absorption inhomogeneities have been introduced. The background effective attenuation was 0.05 cm-1. Several 5 mm diameter inclusions have been introduced in the phantom in different geometries with an effective absorption varying from twice to ten times the background. These inclusions could be detected up to a depth of 4 cm.
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A. Lev, E. Rubanov, B. Sfez, "Quantitative ultrasound modulated light tomography", Proc. SPIE 5697, Photons Plus Ultrasound: Imaging and Sensing 2005: The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, (25 April 2005); doi: 10.1117/12.588559; https://doi.org/10.1117/12.588559
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