14 April 2005 Characterization of thermally induced transitions of collagen using second harmonic generation (SHG) microscopy
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As a major component of the connective tissues, collagen fibers are responsible for various physiological functions inside the body. They provide support for the skin, partial focusing through the cornea, and coordinate movements via tendons, ligaments, and cartilages. In many medical procedures, thermal reorganization of the collagen structure is inevitable or desired. Therefore, the optimization of the therapeutic values of these procedures requires the characterization of thermal changes to collagen fibers. In this presentation, we use multiphoton microscopy to achieve this task. We will show that second harmonic generation (SHG) microscopy can characterize the thermally altered states of collagen and that they have potentials to be used in imaging applications in vivo.
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Yen Sun, Yen Sun, Chih-Yuan Hsiao, Chih-Yuan Hsiao, Shu-Wen Teng, Shu-Wen Teng, Wen Lo, Wen Lo, Hsian-Yuan Tan, Hsian-Yuan Tan, Sung-Jan Lin, Sung-Jan Lin, Gwo-Jen Jan, Gwo-Jen Jan, Wei-Chou Lin, Wei-Chou Lin, Shiou-Hwa Jee, Shiou-Hwa Jee, Chen-Yuan Dong, Chen-Yuan Dong, } "Characterization of thermally induced transitions of collagen using second harmonic generation (SHG) microscopy", Proc. SPIE 5698, Thermal Treatment of Tissue: Energy Delivery and Assessment III, (14 April 2005); doi: 10.1117/12.587176; https://doi.org/10.1117/12.587176

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