Spectroscopic study of tetracycline-lanthanides complexes for biomedical applications

Lilia Coronato Courrol; Flavia Rodrigues de Oliveira Silva; Luis Vicente Gomes Tarelho; Laercio Gomes; Nilson Dias Vieira Jr.

doi:10.1117/12.588773

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4 April 2005 Spectroscopic study of tetracycline-lanthanides complexes for biomedical applications

Lilia Coronato Courrol, Flavia Rodrigues de Oliveira Silva, Luis Vicente Gomes Tarelho, Laercio Gomes, Nilson Dias Vieira Jr.

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Proceedings Volume 5704, Genetically Engineered and Optical Probes for Biomedical Applications III; (2005) https://doi.org/10.1117/12.588773
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Compared with the traditional organic fluorescent materials, the lanthanide coordination compounds have a large variety of applications, for example glucose sensing, based on the luminescence enhancement of a lanthanide-tetracycline complex due to enzymatically generated H₂O₂ at physiological glucose concentrations. It is known that the fluorescence is based on the energy-transfer from the ligand to the central lanthanide ion. The aim of this work was to study the optical properties of Europium, Erbium, Ytterbium, Holmium, Terbium and Neodymium tetracycline complexes. An increase in europium emission band was observed for the first time, with addition of urea peroxide in the solution. This method works at neutral pH and the luminescence was detected at visible lanthanides luminescence after a 10 min. incubation time of the samples.

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Lilia Coronato Courrol, Flavia Rodrigues de Oliveira Silva, Luis Vicente Gomes Tarelho, Laercio Gomes, and Nilson Dias Vieira Jr. "Spectroscopic study of tetracycline-lanthanides complexes for biomedical applications", Proc. SPIE 5704, Genetically Engineered and Optical Probes for Biomedical Applications III, (4 April 2005); https://doi.org/10.1117/12.588773

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