Study of action of cyclophosphamide and extract of mycelium of Pleurotus ostreatus in vivo on mice, bearing melanoma B16-F0-GFP

Irina G. Meerovich; Meng Yang; Ping Jiang; Robert M. Hoffman; Valery P. Gerasimenya; Alexander E. Orlov; Alexander P. Savitsky; Vladimir O. Popov

doi:10.1117/12.592546

4 April 2005 Study of action of cyclophosphamide and extract of mycelium of Pleurotus ostreatus in vivo on mice, bearing melanoma B16-F0-GFP

Irina G. Meerovich, Meng Yang, Ping Jiang, Robert M. Hoffman, Valery P. Gerasimenya, Alexander E. Orlov, Alexander P. Savitsky, Vladimir O. Popov

Author Affiliations +

Proceedings Volume 5704, Genetically Engineered and Optical Probes for Biomedical Applications III; (2005) https://doi.org/10.1117/12.592546
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

In this work we studied in vivo the combined action of cyclophosphamide and the extract of mycelium of Pleurotus ostreatus on mice bearing melanoma B16-F0, expressing green fluorescent protein (GFP). This model allows to recognize small-size tumors and metastases, unrecognizable by other methods. It was found that combined administration of cyclophosphamide (300 mg/kg) and the extract of mycelium of Pleurotus ostreatus (100 mg/kg), administered for 10 days after cyclophosphamide injection, as well administration of cyclophosphamide alone, cause inhibition of tumor growth about 97%. It was shown that administration of the extract of mycelium of Pleurotus ostreatus alone leads to inhibition of tumor growth of 61%. It was found that in case of combined administration of cyclophosphamide and the extract of mycelium of Pleurotus ostreatus, leucopenia was less expressed than in case of administration of cyclophosphamide alone.

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Irina G. Meerovich, Meng Yang, Ping Jiang, Robert M. Hoffman, Valery P. Gerasimenya, Alexander E. Orlov, Alexander P. Savitsky, and Vladimir O. Popov "Study of action of cyclophosphamide and extract of mycelium of Pleurotus ostreatus in vivo on mice, bearing melanoma B16-F0-GFP", Proc. SPIE 5704, Genetically Engineered and Optical Probes for Biomedical Applications III, (4 April 2005); https://doi.org/10.1117/12.592546

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