Near-field optical imaging using optically trapped nanoparticles

A. R. Faustov; V. I. Shcheslavskiy; G. I. Petrov; V. V. Yakovlev

doi:10.1117/12.591324

28 April 2005 Near-field optical imaging using optically trapped nanoparticles

A. R. Faustov, V. I. Shcheslavskiy, G. I. Petrov, V. V. Yakovlev

Proceedings Volume 5705, Nanobiophotonics and Biomedical Applications II; (2005) https://doi.org/10.1117/12.591324
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Our ability to understand the structures and functions of living systems on a cellular and molecular level is mostly determined by the availability of imaging techniques capable of accessing a nanoscopic spatial resolution as well as providing structural information on molecular systems in vivo. While optical methods provide non-invasiveness, their spatial resolution is limited by a fundamental diffraction limit revealed more than 150 years ago by Ernst Abbe. This report addresses this grand-challenge and suggests a novel way of minimally invasive nanoscopic optical imaging inside a living cell. A powerful combination of optical tweezers, nonlinear optics and material science holds a promise of achieving unprecedented resolution of live-cell imaging, which should significantly advance our knowledge of molecular functions on a cellular level.

Citation Download Citation

A. R. Faustov, V. I. Shcheslavskiy, G. I. Petrov, and V. V. Yakovlev "Near-field optical imaging using optically trapped nanoparticles", Proc. SPIE 5705, Nanobiophotonics and Biomedical Applications II, (28 April 2005); https://doi.org/10.1117/12.591324

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