28 April 2005 Synthesis of surface ligands to prepare hydrophilic and biologically compatible quantum dots
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Abstract
We describe a versatile scheme to prepare an array of multidentate surface capping molecules. Such materials permit strong interactions with semiconductor nanocrystals and render them water compatible. These ligands were synthesized by reacting various chain length poly (ethylene glycols) with thioctic acid, followed by ring opening of the dithiolane moiety. Functionalization of CdSe-ZnS quantum dots with these ligands allow processing of the nanocrystals not only in aqueous but in many other polar solvents. Further synthetic processing of the ligands with biotin moieties allowed for investigating assays based on the avidin-biotin interactions. These ligands provide a straightforward means of preparing QDs that exhibit greater resistance to environmental changes, making them more amenable for use in live cell imaging and other biotechnological applications.
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H. Tetsuo Uyeda, Igor L. Medintz, Hedi Mattoussi, "Synthesis of surface ligands to prepare hydrophilic and biologically compatible quantum dots", Proc. SPIE 5705, Nanobiophotonics and Biomedical Applications II, (28 April 2005); doi: 10.1117/12.590494; https://doi.org/10.1117/12.590494
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