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22 January 2005 Optical detection of electrokinetically manipulated single molecules in a nanofluidic chip
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Abstract
We report on the progress of a novel nanofluidic device for detecting and manipulating single molecules in solution. This paper discusses the development of an earlier proposed molecule separation method, where electrokinetic forces separate different molecules based on their masses and charges. Optical imaging using confocal microscopy is applied to perform the detection of the single molecules. Potential applications of this device will be assessed. This research aims for the high spatial and spectral resolutions, both in manipulation and detection, which can lead to molecular identification.
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Gea O. F. Parikesit, Vladimir G. Kutchoukov, Andre Bossche, Ian Theodor Young, and Yuval Garini "Optical detection of electrokinetically manipulated single molecules in a nanofluidic chip", Proc. SPIE 5718, Microfluidics, BioMEMS, and Medical Microsystems III, (22 January 2005); https://doi.org/10.1117/12.583566
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