25 March 2005 Experimental and theoretical study of the THz absorption spectra of selected tripeptides
Author Affiliations +
We investigate small peptides using standard terahertz (THz) time-domain spectroscopy. As a test set we examine the tripeptides glutathione, gly-gly-gly and enalapril maleate at room temperature. While earlier investigations of short-chain polypeptides with a conventional FTIR spectrometer were performed at higher THz frequencies, we present first measurements between 150 GHz and 2 THz and compare our measurements to density functional theory (DFT) calculations in order to assign the measured resonances to distinct molecular motions. DFT calculations obtained for a single molecule (glutathione), dimers (gly-gly-gly) and ion pairs (enalapril maleate) coupled via H-bonds, reproduce correctly the number of resonances observed in the experiment.
© (2005) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Frank Rutz, Frank Rutz, R. Wilk, R. Wilk, T. Kleine-Ostmann, T. Kleine-Ostmann, J. Grunenberg, J. Grunenberg, Martin Koch, Martin Koch, } "Experimental and theoretical study of the THz absorption spectra of selected tripeptides", Proc. SPIE 5727, Terahertz and Gigahertz Electronics and Photonics IV, (25 March 2005); doi: 10.1117/12.590532; https://doi.org/10.1117/12.590532

Back to Top