14 April 2005 Magnetic resonance elastography using time reversed acoustics
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Abstract
Recent efforts in medical imaging have shown that mechanical stimulation of tissues and a suitable imaging modality can be used to interrogate elastic properties of human tissues. Malignant tissues can have elastic properties that allow the physician to separate them from benign counterparts or plaque in arteries can be characterized in regard to its age by measuring its elastic properties. Our system consists of: (1) an acoustic source to induce tissue displacement, (2) a tissue mimicking phantom, and (3) MRI as a method for imaging and measuring the induced shear wave in the phantom. Agar was used to construct a tissue mimicking phantom. A modified spin echo sequence was written to trigger the acoustic system and phase encode the displacement information with magnetic field gradients. A series of images was obtained from the modified multi-slice, spin-echo sequence. Images showed z-axis displacement created by the radiation force. Additional experiments recorded the x and y displacement and allowed for a full 3D vector reconstruction of shear wave propagation. MRI provides a method to record displacements created by radiation force. Acoustical sources can be used to induce shear waves, which in turn can be imaged with MRI methods to quantify and display this wave in a 3D fashion.
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Oliver D. Kripfgans, Oliver D. Kripfgans, Kevin J. Haworth, Kevin J. Haworth, Derek D. Steele, Derek D. Steele, Scott D. Swanson, Scott D. Swanson, } "Magnetic resonance elastography using time reversed acoustics", Proc. SPIE 5746, Medical Imaging 2005: Physiology, Function, and Structure from Medical Images, (14 April 2005); doi: 10.1117/12.596103; https://doi.org/10.1117/12.596103
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