Implementation of sensitivity and resolution modeling for SPECT with cone-beam collimator

Andrzej Krol; Vikram R. Kunniyur; Wei Lee; Kedar R. Gangal; Ioana L. Coman; Edward D. Lipson; Deborah A. Karczewski; F. Deaver Thomas; David H. Feiglin

doi:10.1117/12.596273

29 April 2005 Implementation of sensitivity and resolution modeling for SPECT with cone-beam collimator

Andrzej Krol, Vikram R. Kunniyur, Wei Lee, Kedar R. Gangal, Ioana L. Coman, Edward D. Lipson, Deborah A. Karczewski, F. Deaver Thomas, David H. Feiglin

Author Affiliations +

Proceedings Volume 5747, Medical Imaging 2005: Image Processing; (2005) https://doi.org/10.1117/12.596273
Event: Medical Imaging, 2005, San Diego, California, United States

Abstract

We implemented a fully-3D ordered-subsets expectation-maximization (OSEM) algorithm with attenuation compensation, distance-dependent blurring (DDB), and sensitivity modeling for SPECT performed with a cone-beam collimator (CBC). The experimentally obtained detector response to point sources across FOV was fitted to a two-dimensional Gaussian function with its width (FWHM) varying linearly with the source-to-detector distance and with very weak sensitivity dependence on the emission angle. We obtained CBC SPECT scans of a physical point-source phantom, a Defrise phantom, and a female patient, and we investigated performance of our algorithm. To correctly simulate DDB and sensitivity, a blurring kernel with a radius of up to 10 elements had to be used for a 128x128 acquisition matrix, and volumetric ray tracing rather than line-element-based ray tracing has to be implemented. In the point-source phantom reconstruction we evaluated the uniformity of FWHM for the radial, tangential and longitudinal directions, and sensitivity vs. distance. An isotropic and stationary resolution was obtained at any location by OSEM with DDB and sensitivity modeling, only when volumetric ray tracing was used. We analyzed axial and transaxial profiles obtained for the Defrise phantom and evaluated the reconstructed breast SPECT patient images. The proposed fully-3D OSEM reconstruction algorithm with DBB and sensitivity modeling, and attenuation compensation with volumetric rays tracing is efficient and effective with significant resolution and sensitivity recovery.

Citation Download Citation

Andrzej Krol, Vikram R. Kunniyur, Wei Lee, Kedar R. Gangal, Ioana L. Coman, Edward D. Lipson, Deborah A. Karczewski, F. Deaver Thomas, and David H. Feiglin "Implementation of sensitivity and resolution modeling for SPECT with cone-beam collimator", Proc. SPIE 5747, Medical Imaging 2005: Image Processing, (29 April 2005); https://doi.org/10.1117/12.596273

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Single photon emission computed tomography

Sensors

Collimators

Signal attenuation

Ray tracing

Breast

Expectation maximization algorithms

Show All Keywords

Keywords/Phrases

Search In:

Publication Years