3D perfusion mapping in the intact mouse heart after myocardial infarction using myocardial contrast echocardiography

Yinbo Li; Zequan Yang; Brent A. French; John A. Hossack

doi:10.1117/12.601623

12 April 2005 3D perfusion mapping in the intact mouse heart after myocardial infarction using myocardial contrast echocardiography

Yinbo Li, Zequan Yang, Brent A. French, John A. Hossack

Author Affiliations +

Proceedings Volume 5750, Medical Imaging 2005: Ultrasonic Imaging and Signal Processing; (2005) https://doi.org/10.1117/12.601623
Event: Medical Imaging, 2005, San Diego, California, United States

Abstract

An intact mouse model of surgically-induced myocardial infarction (MI) caused by permanent occlusion of the Left Anterior Descending (LAD) coronary artery was studied. Normal mice with no occlusion were also studied as controls. For each mouse, contrast enhanced ultrasound images of the heart were acquired in parallel cross-sections perpendicular to the sternum at millimeter increments. For accurate 3D reconstruction, ECG gating and a tri-axial adjustable micromanipulator were used for temporal and spatial registration. Ultrasound images at steady-state of blood refilling were color-coded in each slice to show relative perfusion. Myocardial perfusion defects and necrosis were also examined postmortem by staining with Phthalo blue and TTC red dyes. Good correlation (R>0.93) in perfused area size was observed between in vivo measurements and histological staining. A 3D multi-slice model and a 3D rendering of perfusion distribution were created and showed a promising match with postmortem results, lending further credence to its use as a more comprehensive and more reliable tool for in vivo assessment of myocardial perfusion than 2D tomographic analysis.

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Yinbo Li, Zequan Yang, Brent A. French, and John A. Hossack "3D perfusion mapping in the intact mouse heart after myocardial infarction using myocardial contrast echocardiography", Proc. SPIE 5750, Medical Imaging 2005: Ultrasonic Imaging and Signal Processing, (12 April 2005); https://doi.org/10.1117/12.601623

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KEYWORDS

Heart

3D modeling

Ultrasonography

In vivo imaging

Scanners

Echocardiography

Mouse models

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