12 April 2005 Using light-scattering techniques to better understand the interaction of pulsed ultrasound with contrast microbubbles
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Abstract
It is important to understand the interaction of pulsed ultrasound with ultrasound contrast agents so that the agents can be utilized to their fullest. Towards this goal, we have optimized light-scattering to provide quantitative information about microbubble oscillations when subjected to diagnostic ultrasound pulses. Initial experiments were performed with individual microbubbles. Pulses from actual diagnostic imaging systems were used to 'activate' the microbubbles. Bubble oscillations were measured by focusing the scattered light onto a photodetector. Data was collected with a fast oscilloscope set up to capture instantaneous bubble oscillation data for many consecutive ultrasound pulses. Results for individual bubbles show that at low pressures, the bubbles can be stable for many pulses. Sometimes, the bubbles evolve, presumably due to shell permeabilization and shell fatigue. Bubble dynamics models compare favorably with the observed oscillations. Light scattering can be an important tool for understanding and optimizing newer bubble imaging modes such as pulse inversion.
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Thomas J. Matula, Thomas J. Matula, Jingfeng Guan, Jingfeng Guan, } "Using light-scattering techniques to better understand the interaction of pulsed ultrasound with contrast microbubbles", Proc. SPIE 5750, Medical Imaging 2005: Ultrasonic Imaging and Signal Processing, (12 April 2005); doi: 10.1117/12.595847; https://doi.org/10.1117/12.595847
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