Luminescent probe in the study of surfactant-induced structural changes in serum albumin in human blood plasma

A. G. Melnikov; A. B. Pravdin; V. I. Kochubey; G. V. Melnikov

doi:10.1117/12.634650

22 June 2005 Luminescent probe in the study of surfactant-induced structural changes in serum albumin in human blood plasma

A. G. Melnikov, A. B. Pravdin, V. I. Kochubey, G. V. Melnikov

Author Affiliations +

Proceedings Volume 5771, Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI; (2005) https://doi.org/10.1117/12.634650
Event: Saratov, Russia, 2004, Saratov, Russian Federation

Abstract

The luminescence-kinetic technique of the monitoring of structural changes in albumins of human blood plasma that uses a luminescent probe-eosin is proposed. Phosphorescence of eosin bound to the globular proteins of blood plasma-albumins was recorded at room temperature. It is found that under the action of sodium dodecylsulfate on the albumins the rate constant of eosin phosphorescence decay grows and the intensity of eosin phosphorescence decreases. It is assumed that these changes are connected with the denaturing of blood plasma albumins by sodium dodecylsulfate.

Citation Download Citation

A. G. Melnikov, A. B. Pravdin, V. I. Kochubey, and G. V. Melnikov "Luminescent probe in the study of surfactant-induced structural changes in serum albumin in human blood plasma", Proc. SPIE 5771, Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI, (22 June 2005); https://doi.org/10.1117/12.634650

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE