Optical methods in modeling nicotine effect on the surface water of cell membranes

Tatyana V. Alexandrova; Svetlana M. Rogacheva; Pavel E. Kuznetsov; Tamara I. Gubina

doi:10.1117/12.634831

22 June 2005 Optical methods in modeling nicotine effect on the surface water of cell membranes

Tatyana V. Alexandrova, Svetlana M. Rogacheva, Pavel E. Kuznetsov, Tamara I. Gubina

Proceedings Volume 5771, Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI; (2005) https://doi.org/10.1117/12.634831
Event: Saratov, Russia, 2004, Saratov, Russian Federation

Abstract

Fluorescence and spectrophotometric methods have been used for investigation of nicotine action on the state and mobility of the surface water. The surfaces of membranes and proteins were simulated with the help of liposomes and ultradispersive diamonds consequently. Nicotine was shown to reduce the stability of liposomes and to change the aggregative ability of ultradispersive diamonds. The wave-like curves for the nicotine concentration dependences of the pointed features were observed. Such shape of responses was suggested to be due to the changing in structure and dynamics of water hydrogen bonds net near the surface of the model systems induced by nicotine molecules. The surface water phase was supposed to be one of signal elements ofthe ligand receptor recognition process.

Citation Download Citation

Tatyana V. Alexandrova, Svetlana M. Rogacheva, Pavel E. Kuznetsov, and Tamara I. Gubina "Optical methods in modeling nicotine effect on the surface water of cell membranes", Proc. SPIE 5771, Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI, (22 June 2005); https://doi.org/10.1117/12.634831

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available