9 June 2005 Experimental determination of optical and mechanical properties of an optical elastography phantom
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We report the results of experiments conducted to determine optical and mechanical properties of tissue mimicking phantoms that are designed for optical elastography. In optical elastography the readout mechanism for displacement is optical, and the mechanical and optical properties of the phantom are to be tailored to match those of the tissue being imaged. The optical characterization is based on diffusive nature of light propagation including scattering anisotropy and boundary reflection. The anisotropy factor (g) is measured using a relatively thin sample (where single scattering assumption is valid) through experimentally measuring the angular intensity transmittance. The measured intensity distributions are fitted to, known theoretically available intensity distributions, which have scattering anisotropy (g) as one of the parameters, to extract g. The scattering coefficient (μS) and refractive index (n) are obtained using a thicker slab (multiple scattering regime) from where angle-resolved intensity transmittance is measured. Computed intensity distributions using Monte-Carlo(MC) simulations are curve fitted to extract 'μs' and 'n' which are used in the Monte-Carlo simulation. The visco-elastic properties such as frequency dependent elastic and loss moduli of the phantom are determined by measuring the complex modulus using a dynamic mechanical analyzing system.
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C. Usha Devi Amma, C. Usha Devi Amma, R. M. Vasu, R. M. Vasu, A. K. Sood, A. K. Sood, } "Experimental determination of optical and mechanical properties of an optical elastography phantom", Proc. SPIE 5772, Saratov Fall Meeting 2004: Coherent Optics of Ordered and Random Media V, (9 June 2005); doi: 10.1117/12.636893; https://doi.org/10.1117/12.636893

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