Development of a PCR free, fieldable, rapid, accurate, and sensitive bio-electronic DNA biosensor

Doyle Hill; David Chafin; Roberta Greco; Samina Jafri; Richard Murante; John Noonan; An Pham; Scott Seabridge; Vera Tannous; Karl VanDerMeid; Daguang Wang; Nate Wescott; Kristin McFarlane; Sanjiv Shah

doi:10.1117/12.606722

20 May 2005 Development of a PCR free, fieldable, rapid, accurate, and sensitive bio-electronic DNA biosensor

Doyle Hill, David Chafin, Roberta Greco, Samina Jafri, Richard Murante, John Noonan, An Pham, Scott Seabridge, Vera Tannous, Karl VanDerMeid, Daguang Wang, Nate Wescott, Kristin McFarlane, Sanjiv Shah

Author Affiliations +

Proceedings Volume 5778, Sensors, and Command, Control, Communications, and Intelligence (C3I) Technologies for Homeland Security and Homeland Defense IV; (2005) https://doi.org/10.1117/12.606722
Event: Defense and Security, 2005, Orlando, Florida, United States

Abstract

The objective of this study was to demonstrate proof of concept for the Integrated Nano-Technologies BioDetect Bacillus anthracis electronic DNA sensor. B. anthracis Ames strain DNA was successfully detected by the formation of DNA bridges on the sensor. The bridges were coated with metal, resulting in a significant drop in electrical resistance. In this small test, at a relatively high DNA concentration, the overall accuracy of the sensor was 90.7%. The technology shows significant promise for future development as a bio-agent detection system.

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Doyle Hill, Doyle Hill, David Chafin, David Chafin, Roberta Greco, Roberta Greco, Samina Jafri, Samina Jafri, Richard Murante, Richard Murante, John Noonan, John Noonan, An Pham, An Pham, Scott Seabridge, Scott Seabridge, Vera Tannous, Vera Tannous, Karl VanDerMeid, Karl VanDerMeid, Daguang Wang, Daguang Wang, Nate Wescott, Nate Wescott, Kristin McFarlane, Kristin McFarlane, Sanjiv Shah, Sanjiv Shah, } "Development of a PCR free, fieldable, rapid, accurate, and sensitive bio-electronic DNA biosensor", Proc. SPIE 5778, Sensors, and Command, Control, Communications, and Intelligence (C3I) Technologies for Homeland Security and Homeland Defense IV, (20 May 2005); doi: 10.1117/12.606722; https://doi.org/10.1117/12.606722

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