Novel, cost-efficient, and highly-sensitive IR imaging systems play an important role in homeland security functions. Technical limitations in the areas of sensitivity, contrast ratio, bandwidth and cost continue to constrain imaging capabilities. We have designed and prototyped a compact computer-piloted high sensitivity infrared imaging system. The device consists of infrared optics, cryostat, low-noise pre-amplifier, Analog-to-Digital hardware, feedback electronics, and unique image processing software. Important advantages of the developed system are: (i) Eight electronic channels are available for simultaneous registration of IR and visible images in multiple spectral ranges, (ii) Capability of real-time analysis such as comparing the “sensed” image with “reference” images from a database, (iii) High accuracy temperature measurement of multiple points on the image by referencing the radiation intensity from the object to a black body model, (iv) Image generation by real-time integration of images from multiple sensors operating from the visible to the terahertz range. The device was tested with a liquid-nitrogen-cooled, single-pixel HgCdTe detector for imaging in 8-12 microns range. The demonstrated examples of infrared imaging of concealed objects in static and dynamic modes include a hammer (metal head and wooden handle), plastic imitator of handguns hidden under clothes, powder in an envelope, and revealing complex wall structures under decorative plaster.