Artificial bilayer lipid membranes (BLMs) on-chip for single molecule sensing

Mairi E. Sandison; Daniele Malleo; David Holmes; Richard Berry; Hywel Morgan

doi:10.1117/12.608645

Translator Disclaimer

28 June 2005 Artificial bilayer lipid membranes (BLMs) on-chip for single molecule sensing

Mairi E. Sandison, Daniele Malleo, David Holmes, Richard Berry, Hywel Morgan

Author Affiliations +

Proceedings Volume 5838, Nanotechnology II; (2005) https://doi.org/10.1117/12.608645
Event: Microtechnologies for the New Millennium 2005, 2005, Sevilla, Spain

Abstract

A polymer microfluidic device for the formation of artificial bilayer lipid membranes (BLMs) on-chip is described. The device is fabricated from thin, transparent films of poly(methyl methacrylate), allowing for optical monitoring of the BLM. In addition, detection of single fluorescently-labeled lipid molecules using conventional epifluorescence microscopy is described.

Citation Download Citation

Mairi E. Sandison, Daniele Malleo, David Holmes, Richard Berry, and Hywel Morgan "Artificial bilayer lipid membranes (BLMs) on-chip for single molecule sensing", Proc. SPIE 5838, Nanotechnology II, (28 June 2005); https://doi.org/10.1117/12.608645

ACCESS THE FULL ARTICLE