Observation of a power law memory kernel for distance fluctuation within a single protein molecule

Wei Min; Guobin Luo; Binny J. Cherayil; Samuel C. Kou; X. Sunney Xie

doi:10.1117/12.608514

23 May 2005 Observation of a power law memory kernel for distance fluctuation within a single protein molecule

Wei Min, Guobin Luo, Binny J. Cherayil, Samuel C. Kou, X. Sunney Xie

Proceedings Volume 5841, Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems III; (2005) https://doi.org/10.1117/12.608514
Event: SPIE Third International Symposium on Fluctuations and Noise, 2005, Austin, Texas, United States

Abstract

The fluctuation of the distance between a fluorescein-tyrosine pair within a single protein complex was directly monitored in real time by photo-induced electron transfer, and found to be a stationary, time-reversible and non-Markovian Gaussian process. Within the generalized Langevin equation (GLE) formalism, we experimentally determine the memory kernel, K(t), which is proportional to the autocorrelation function of the random fluctuating force. K(t) is a power-law decay, t^{- 0.51 ± 0.07} in a broad range of time-scales (10^-3 s -10s. Such a long time memory effect, which is associated with sub-diffusion within a harmonic bound, has implications to protein functions.

Citation Download Citation

Wei Min, Guobin Luo, Binny J. Cherayil, Samuel C. Kou, and X. Sunney Xie "Observation of a power law memory kernel for distance fluctuation within a single protein molecule", Proc. SPIE 5841, Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems III, (23 May 2005); https://doi.org/10.1117/12.608514

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