23 May 2005 Simulation of near infrared spectroscopy with ICG on an adult head
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Proceedings Volume 5855, 17th International Conference on Optical Fibre Sensors; (2005) https://doi.org/10.1117/12.624390
Event: 17th International Conference on Optical Fibre Sensors, 2005, Bruges, Belgium
Abstract
Conventional near infrared spectroscopy (NIRS) for oxymetry has been extended recently with an indocyanine green (ICG) dye dilution method. The injection of ICG allows estimation of cerebral blood volume (CBV ), the mean transit time (mttICG) and the cerebral blood flow (CBF) from the optical density signals. However, the optical density signal obtained through the skull is substantially in influenced by extracerebral tissue. Monte Carlo simulation is used to simulate for the first time light propagation during NIRS with ICG to characterize extracerebral contamination. Simulations are performed on the anatomical structure of an adult head obtained using 3D-magnetic resonance imaging (MRI). ICG is modelled by increasing the absorption coefficients of the tissues, taking their relative blood volumes into account. The effect of ICG on extracerebral contamination of NIRS signals is discussed.
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R. Mudra, P. Niederer, E. Keller, "Simulation of near infrared spectroscopy with ICG on an adult head", Proc. SPIE 5855, 17th International Conference on Optical Fibre Sensors, (23 May 2005); doi: 10.1117/12.624390; https://doi.org/10.1117/12.624390
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