7 October 2005 Interferometric tracking of two particles with dynamic optical traps
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Abstract
Optical potential landscapes for diffusing particles can be generated by time-multiplexing (scanning) an optical trap and additionally modulating the trapping laser power. We show that it is possible to determine the lateral and axial positions of several particles in parallel with some 10 nm precision and at kHz rates by using dynamic back focal plane interferometry. This allows measuring the interaction of diffusing, (non-) functionalized particles in a confined volume. The scan frequency of the optical trap can be optimized for interaction measurements with high dynamic or temporal resolution, given a data sampling frequency of 1MHz.
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Dirk Neumayer, Dirk Neumayer, Peter Kaiser, Peter Kaiser, Ernst H.K. Stelzer, Ernst H.K. Stelzer, Alexander Rohrbach, Alexander Rohrbach, } "Interferometric tracking of two particles with dynamic optical traps", Proc. SPIE 5859, Photon Migration and Diffuse-Light Imaging II, 58590A (7 October 2005); doi: 10.1117/12.632831; https://doi.org/10.1117/12.632831
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