7 October 2005 System for the measurement of blood flow and oxygenation in tissue applied to neurovascular coupling in brain
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Abstract
We designed a system incorporating the independent measurement of blood flow and oxygenation of haemoglobin. This is based on laser-Doppler spectroscopy with NIR wavelengths which gives a measure for changes in blood flow or tissue perfusion as well as reflectance spectroscopy in the VIS wavelength range for the calculation of the oxygenated and deoxygenated haemoglobin components. The co-registration of these parameters allows the neurovascular coupling of brain to be investigated. This is demonstrated by recording functional activity of the rat brain during electrical forepaw stimulation.
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Matthias Kohl-Bareis, Matthias Kohl-Bareis, Christoph Leithner, Christoph Leithner, Heike Sellien, Heike Sellien, Roland Guertler, Roland Guertler, Dmitri Geraskin, Dmitri Geraskin, Benjamin Rohrer, Benjamin Rohrer, Georg Royl, Georg Royl, Ulrich Dirnagl, Ulrich Dirnagl, Ute Lindauer, Ute Lindauer, "System for the measurement of blood flow and oxygenation in tissue applied to neurovascular coupling in brain", Proc. SPIE 5859, Photon Migration and Diffuse-Light Imaging II, 58590F (7 October 2005); doi: 10.1117/12.632835; https://doi.org/10.1117/12.632835
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