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7 October 2005 Common-path Fourier domain optical coherence tomography of irradiated human skin and ventilated isolated rabbit lungs
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Abstract
A compact common path Fourier domain optical coherence tomography (FD-OCT) system based on a broadband superluminescence diode is used for biomedical imaging. The epidermal thickening of human skin after exposure to ultraviolet radiation is measured to proof the feasibility of FD-OCT for future substitution of invasive biopsies in a long term study on natural UV skin protection. The FD-OCT system is also used for imaging lung parenchyma. FD-OCT images of a formalin fixated lung show the same alveolar structure as scanning electron microscopy images. In the ventilated and blood-free perfused isolated rabbit lung FD-OCT is used for real-time cross-sectional image capture of alveolar mechanics throughout tidal ventilation. The alveolar mechanics changing from alternating recruitment-derecruitment at zero positive end-expiratory pressure (PEEP) to persistent recruitment after applying a PEEP of 5 cm H2O is observed in the OCT images.
© (2005) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
A. Popp, M. Wendel, L. Knels, P. Knuschke, M. Mehner, T. Koch, D. Boller D.V.M., P. Koch, and E. Koch "Common-path Fourier domain optical coherence tomography of irradiated human skin and ventilated isolated rabbit lungs", Proc. SPIE 5861, Optical Coherence Tomography and Coherence Techniques II, 58610Q (7 October 2005); https://doi.org/10.1117/12.632984
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