In vivo and ex vivo imaging with ultrahigh resolution full-field OCT

Kate Grieve; Gael Moneron; Wilfrid Schwartz; Albert Claude Boccara; Arnaud Dubois

doi:10.1117/12.632997

7 October 2005 In vivo and ex vivo imaging with ultrahigh resolution full-field OCT

Kate Grieve, Gael Moneron, Wilfrid Schwartz, Albert Claude Boccara, Arnaud Dubois

Proceedings Volume 5861, Optical Coherence Tomography and Coherence Techniques II; 586113 (2005) https://doi.org/10.1117/12.632997
Event: European Conferences on Biomedical Optics 2005, 2005, Munich, Germany

Abstract

Imaging of in vivo and ex vivo biological samples using full-field optical coherence tomography is demonstrated. Three variations on the original full-field optical coherence tomography instrument are presented, and evaluated in terms of performance. The instruments are based on the Linnik interferometer illuminated by a white light source. Images in the en face orientation are obtained in real-time without scanning by using a two-dimensional parallel detector array. An isotropic resolution capability better than 1 μm is achieved thanks to the use of a broad spectrum source and high numerical aperture microscope objectives. Detection sensitivity up to 90 dB is demonstrated. Image acquisition times as short as 10 μs per en face image are possible. A variety of in vivo and ex vivo imaging applications is explored, particularly in the fields of embryology, ophthalmology and botany.

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Kate Grieve, Gael Moneron, Wilfrid Schwartz, Albert Claude Boccara, and Arnaud Dubois "In vivo and ex vivo imaging with ultrahigh resolution full-field OCT", Proc. SPIE 5861, Optical Coherence Tomography and Coherence Techniques II, 586113 (7 October 2005); https://doi.org/10.1117/12.632997

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KEYWORDS

Optical coherence tomography

In vivo imaging

Image resolution

Ophthalmology

Imaging systems

Interferometers

Light sources

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