Infrared free electron laser enhanced transdermal drug delivery

Kunio Awazu; Takeyuki Uchizono; Sachiko Suzuki; Kazushi Yoshikawa

doi:10.1117/12.633107

26 August 2005 Infrared free electron laser enhanced transdermal drug delivery

Kunio Awazu, Takeyuki Uchizono, Sachiko Suzuki, Kazushi Yoshikawa

Proceedings Volume 5863, Therapeutic Laser Applications and Laser-Tissue Interactions II; 58630N (2005) https://doi.org/10.1117/12.633107
Event: European Conferences on Biomedical Optics 2005, 2005, Munich, Germany

Abstract

It is necessary to control enhancement of transdermal drug delivery with non-invasive. The present study was investigated to assess the effectivity of enhancing the drug delivery by irradiating 6-μm region mid infrared free electron laser (MIR-FEL). The enhancement of transdermal drug (lidocaine) delivery of the samples (hairless mouse skin) irradiated with lasers was examined for flux (μg/cm²/h) and total penetration amount (μg/cm²) of lidocaine by High performance Liquid Chromatography (HPLC). The flux and total amount penatration date was enhanced 200-300 fold faster than the control date by the laser irradiation. FEL irradiating had the stratum corneum, and had the less thermal damage in epidermis. The effect of 6-μm region MIR-FEL has the enhancement of transdermal drug delivery without removing the stratum corneum because it has the less thermal damage. It leads to enhancement drug delivery system with non-invasive laser treatment.

Citation Download Citation

Kunio Awazu, Takeyuki Uchizono, Sachiko Suzuki, and Kazushi Yoshikawa "Infrared free electron laser enhanced transdermal drug delivery", Proc. SPIE 5863, Therapeutic Laser Applications and Laser-Tissue Interactions II, 58630N (26 August 2005); https://doi.org/10.1117/12.633107

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