26 August 2005 Selective damage of coloration centers inhomogeneously distributed in skin tissue under nanosecond near-IR laser pulses
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Abstract
The results are presented on the study of the damage of melanin granules contained in ex-vivo animal skin specimens under a series of single Nd:glass laser pulses of nanosecond duration, with intensity I ~ 108 W/cm2. The mechanism responsible for tissue damage at the given conditions is shown to be a selective photodisruption occurring due to preferential energy absorption by endogenic skin pigment. For such a complicated multicomponent structure as biotissue comprising substructures inhomogeneously distributed in the bulk of it and differing in physical and chemical properties, such a parameter as volume energy density becomes a decisive one for tissue damage. When its magnitude reaches the damage threshold value within the absorption loci it breaks whereas the surrounding tissue remains undisturbed.
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Ludmila V. Chernyshova, Ludmila V. Chernyshova, Dmitrii M. Kulakov, Dmitrii M. Kulakov, Vladimir M. Chernyak, Vladimir M. Chernyak, "Selective damage of coloration centers inhomogeneously distributed in skin tissue under nanosecond near-IR laser pulses", Proc. SPIE 5863, Therapeutic Laser Applications and Laser-Tissue Interactions II, 58630O (26 August 2005); doi: 10.1117/12.633108; https://doi.org/10.1117/12.633108
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