26 August 2005 Fluorescence guided evaluation of photodynamic therapy as acne treatment
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Abstract
Photodynamic therapy (PDT) is an attractive alternative treatment for patients with acne because of its efficiency and few side effects. Propionibacterium acnes (P.acnes) are bacteria present in the skin, which produce endogenous porphyrins that act as photosensitisers. In addition, application of aminolaevulinic acid or its methyl ester (mALA) results in increased accumulation of porphyrins in the pilosebaceous units. This makes it possible to treat acne with PDT. This initial study investigates the possibility of fluorescence imaging as assessment tool in adjunct to PDT of patients with acne. Twenty-four patients with acne on the cheeks have been treated with PDT with and without mALA. Fluorescence images have been obtained before and after treatment. The clinical acne score was assessed as base line before PDT, and at every follow up visit. Additionally the amount of P.acnes was determined. The clinical evaluation showed a general improvement of acne, even though no difference between treatment with and without mALA was observed. By performing texture analysis and multivariate data analsysis on the fluorescence images, the extracted texture features were found to correlate with the corresponding clinical assessment (67%) and amount of P.acnes (72%). The analysis showed that features describing the highly fluorescent pores could be related to the clinical assessment. This result suggests that fluorescence imaging can be used as an objective assessment of acne, but further improvement of the technique is possible, for example by including colour images.
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Marica B. Ericson, Marica B. Ericson, Camilla Horfelt, Camilla Horfelt, Elaine Cheng, Elaine Cheng, Frida Larsson, Frida Larsson, Olle Larko, Olle Larko, Ann-Marie Wennberg, Ann-Marie Wennberg, } "Fluorescence guided evaluation of photodynamic therapy as acne treatment", Proc. SPIE 5863, Therapeutic Laser Applications and Laser-Tissue Interactions II, 58630Y (26 August 2005); doi: 10.1117/12.633095; https://doi.org/10.1117/12.633095
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